GLUT inhibitor WZB117 induces cytotoxicity with increased production of amyloid-beta peptide in SH-SY5Y cells preventable by beta-hydroxybutyrate: implications in Alzheimer's disease.

Gourav ChandanUpasana GangulySoumya PalSukhpal SinghReena V SainiSankha Shubhra ChakrabartiAdesh K SainiSasanka Chakrabarti

Published in: Pharmacological reports : PR (2023)

Results in this neuroblastoma model have implications for the pathogenesis of Alzheimer's disease and warrant further explorations of WZB117 in primary cultures of neurons and experimental animal models.

Keyphrases

cognitive decline
induced apoptosis
cell cycle arrest
emergency department
oxidative stress
cell death
signaling pathway
pi k akt