Ovarian hormones modulate multidrug resistance transporters in the ovary.
Lynae M BrayboyLaura O KnapikSokunvichet LongMollie WestrickGary M WesselPublished in: Contraception and reproductive medicine (2018)
Progesterone appears to influence MDR-1 transcript levels, or steady state levels. This could have implications for better understanding how MDR-1 can be modulated during times of toxic exposure. Understanding the normal physiology of MDR-1 in the ovary will expand the current knowledge in cancer biology and reproduction.