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Maternal Serum Activin A, Inhibin A and Follistatin-Related Proteins across Preeclampsia: Insights into Their Role in Pathogenesis and Prediction.

Jorge A BarreroLaura M Villamil-CamargoJose N ImazKaren Arciniegas-VillaJorge Andrés Rubio-Romero
Published in: Journal of mother and child (2023)
In preeclampsia, inhibin A is upregulated in all trimesters, whereas activin A increases exclusively in the late second and third trimesters. Serum follistatin levels are reduced in women with preeclampsia during the late second and third trimesters. However, changes in follistatin-like 3 remain inconclusive. Inhibin A and activin A can potentially serve as biomarkers of early-onset preeclampsia based on the outcomes of the receiver operating characteristic curve analysis. Further investigations are encouraged to explore the feasibility of quantifying maternal serum levels of activin A and inhibin A as a clinical tool in early preeclampsia prediction.
Keyphrases
  • early onset
  • late onset
  • pregnancy outcomes
  • birth weight
  • metabolic syndrome
  • type diabetes
  • adipose tissue
  • body mass index
  • weight loss
  • insulin resistance