Macrophage-Derived GSDMD Plays an Essential Role in Atherosclerosis and Cross Talk Between Macrophages via the Mitochondria-STING-IRF3/NF-κB Axis.

Xiaoxi Fan Jibo HanLingfeng ZhongWenyuan ZhengRuiyin ShaoYucong ZhangSi ShiShuang LinZhou-Qing Huang Wei-Jian Huang Xueli Cai Bozhi Ye

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Our study has provided a novel macrophage-derived GSDMD mechanism in the promotion of atherosclerosis and demonstrated that GSDMD can be a potential therapeutic target for atherosclerosis.

Keyphrases

cardiovascular disease
adipose tissue
signaling pathway
cell death
oxidative stress
lps induced
dendritic cells
type diabetes
pi k akt
nuclear factor
risk assessment
inflammatory response
human health
cell proliferation
immune response
climate change