Abdominal obesity and alcohol use modify the impact of genetic risk for incident advanced liver disease in the general population.

Panu K Luukkonen Martti FärkkiläAntti JulaVeikko SalomaaSatu MännistöAnnamari LundqvistMarkus PerolaFredrik O Åberg

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

The effect of multiple genetic variants on the risk of ILD is potentiated by abdominal obesity and alcohol use. Simple GRSs may help to identify individuals with adverse lifestyle who are at a particularly high risk of ILD.

Keyphrases

metabolic syndrome
weight loss
interstitial lung disease
insulin resistance
high fat diet induced
type diabetes
weight gain
cardiovascular disease
systemic sclerosis
rheumatoid arthritis
genome wide
skeletal muscle
body mass index
gene expression
dna methylation
idiopathic pulmonary fibrosis
breast cancer risk