Long-term Outcomes of Exercise Therapy versus Revascularization in Patients with Intermittent Claudication.

Although there is equivalent risk of progression to CLTI, major amputation and all-cause mortality compared to non-invasive treatment, invasive treatment for patients with IC led to significantly more revascularization procedures and should be used selectively in patients with major lifestyle limitation. Guideline recommendation of non-invasive treatment for first-line IC therapy is supported.