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The role of fecal calprotectin in pediatric disease.

Su Jin Jeong
Published in: Korean journal of pediatrics (2019)
Fecal calprotectin (FC) is a calcium- and zinc-binding protein of the S100 family, mainly expressed by neutrophils and released during inflammation. FC became an increasingly useful tool both for gastroenterologists and for general practitioners for distinguishing inflammatory bowel disease (IBD) from irritable bowel syndrome. Increasing evidences support the use of this biomarker for diagnosis, follow-up and evaluation of response to therapy of several pediatric gastrointestinal diseases, ranging from IBD to nonspecific colitis and necrotizing enterocolitis. This article summarizes the current literature on the use of FC in clinical practice.
Keyphrases
  • irritable bowel syndrome
  • ulcerative colitis
  • binding protein
  • clinical practice
  • systematic review
  • oxidative stress
  • disease activity
  • systemic lupus erythematosus
  • stem cells
  • mesenchymal stem cells
  • preterm infants