Persistent sodium current blockers can suppress seizures caused by loss of low-threshold D-type potassium currents: Predictions from an in silico study of Kv1 channel disorders.

Published in: Epilepsia open (2020)

Riluzole reduces persistent sodium currents and excitatory postsynaptic currents from NMDA receptor activation. Our results suggest that this FDA-approved drug can be repurposed to treat epilepsies caused by mutations affecting axonal Kv1 channels.

Keyphrases

molecular docking
emergency department
computed tomography
magnetic resonance imaging
optic nerve
electronic health record
adverse drug
peripheral nerve