Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure.
Mario TranfaLuigi LorenziniLyduine E CollijDavid Vállez GarcíaSilvia IngalaGiuseppe PontilloLeonard PieperhoffAlessio MaranzanoRobin WolzSven HallerKaj BlennowGiovanni FrisoniCarole H SudreGaëlle ChételatMichael EwersPierre PayouxAdam WaldmanPablo Martínez-LageAdam J SchwarzCraig W RitchieJoanna Marguerite WardlawJuan Domingo GispertArturo BrunettiHenk-Jan Mm MutsaertsAlle Meije WinkFrederik BarkhofPublished in: Annals of clinical and translational neurology (2024)
Our results suggest that AD pathology and cSVD exert independent and spatially different effects on WM microstructure, supporting the role of DTI in disease monitoring and suggesting independent targets for preventive medicine approaches.
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