New Diterpenes with a Fused 6-5-6-6 Ring System Isolated from the Marine Sponge-Derived Fungus Trichoderma harzianum.
Takeshi YamadaAyano FujiiTakashi KikuchiPublished in: Marine drugs (2019)
New diterpenes, namely, trichodermanins F-H, with a fused 6-5-6-6 ring system were isolated from the fungus Trichoderma harzianum OUPS-111D-4 separated from a marine sponge Halichondria okadai. These chemical structures were elucidated by 1D and 2D NMR as well as high-resolution fast atom bombardment mass spectrometry (HRFABMS) spectral analyses. We established their absolute stereostructures by application of the modified Mosher's method or circular dichroism (CD) spectroscopy. In addition, their cytotoxicities were assessed using several cancer cell lines, with 1 and 2 exhibiting modest activities.
Keyphrases
- high resolution
- mass spectrometry
- papillary thyroid
- liquid chromatography
- optical coherence tomography
- squamous cell
- molecular dynamics
- tandem mass spectrometry
- high speed
- high performance liquid chromatography
- magnetic resonance imaging
- capillary electrophoresis
- lymph node metastasis
- computed tomography
- solid state
- childhood cancer
- magnetic resonance
- nk cells
- dual energy
- electron transfer