Inhibition of post-surgery tumour recurrence via a sprayable chemo-immunotherapy gel releasing PD-L1 antibody and platelet-derived small EVs.
Jian ZhaoHao YeQi LuKaiyuan WangXiaofeng ChenJiaxuan SongHelin WangYutong LuMaosheng ChengZhonggui HeYinglei ZhaiHaotian ZhangJin SunPublished in: Journal of nanobiotechnology (2022)
Our findings indicated that the immunotherapeutic fibrin gel could "awaken" the host innate immune system to inhibit both local tumour recurrence post-surgery and metastatic potential, thus, it could serve as a promising approach to prevent tumour recurrence.