Pathways linked to unresolved inflammation and airway remodelling characterize the transcriptome in two independent severe asthma cohorts.

Stephany Sánchez-Ovando Stelios PavlidisNazanin Zounemat KermaniKatherine Joanne BainesDaniel BarkerPeter Gerard Gibson Lisa G Wood Issssswan M Adcock Kian Fan Chung Jodie Louise Simpson Peter A B Wark

Published in: Respirology (Carlton, Vic.) (2022)

T cells, mast cells and pathways linked to ongoing airway remodelling, such as IL18R1, SUMOylation and NRF2 pathways, as likely active mechanisms in the pathogenesis of SA.

Keyphrases

oxidative stress
gene expression
genome wide
rna seq
dna methylation