Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice.

Matthew SimonMarie Xun WangOzama IsmailMolly BraunAbigail G SchindlerJesica ReemmerZhongya WangMariya A HaveliwalaRyan P O'BoyleWarren Y HanNatalie RoeseMarjorie GrafeRandall WoltjerDetlev BoisonJeffrey J Iliff

Published in: Alzheimer's research & therapy (2022)

These findings suggest that the loss of perivascular AQP4 localization may contribute to the development of AD pathology in human populations.

Keyphrases

endothelial cells
induced pluripotent stem cells
high fat diet induced
metabolic syndrome
type diabetes
adipose tissue
skeletal muscle