Adipose-derived mesenchymal stem cells secrete extracellular vesicles: A potential cell-free therapy for canine renal ischaemia-reperfusion injury.

Hai-Feng LiuLiyuan HuangFuhao ChenZhijun ZhongXiaoping MaZiyao ZhouSuizhong CaoLiuhong ShenGuangneng Peng

Published in: Veterinary medicine and science (2023)

Secretion of EVs by ADMSCs exhibited therapeutic potential in renal IR injury and may lead to a cell-free therapy for canine renal IR injury. These findings revealed that canine ADMSC-EVs potently attenuate renal IR injury-induced renal dysfunction, inflammation and apoptosis, possibly by reducing mitochondrial damage.

Keyphrases

cell free
oxidative stress
mesenchymal stem cells
diabetic rats
heart failure
circulating tumor
left ventricular
climate change
high glucose
cell cycle arrest
drug induced
brain injury
endothelial cells