Disc degeneration spreads: long-term behavioural, histologic and radiologic consequences of a single-level disc injury in active and sedentary mice.

Magali Millecamps Seunghwan Lee Daniel Z Foster Laura S Stone

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2021)

Mechanical injury of L4/5-IVDs induces delayed radiating pain and degeneration of adjacent discs; increased physical activity positively mitigated both.

Keyphrases

physical activity
chronic pain
pain management
body mass index
neuropathic pain
high fat diet induced
spinal cord injury
spinal cord
depressive symptoms