Methyltransferase 1 is required for nonhomologous end-joining repair and renders hepatocellular carcinoma resistant to radiotherapy.
Junbin LiaoYang YiXin YueXiaoxue WuMeiyan ZhuYong ChenSui PengMing KuangShuibin LinZhenwei PengPublished in: Hepatology (Baltimore, Md.) (2022)
Our findings show that METTL1 is a critical enhancer for HCC cell NHEJ-based DNA repair following IR therapy. These findings give insight into the role of tRNA modification in messenger RNA translation control in HCC radioresistance.