Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection.
Sarah HendrickxLieselotte Van BockstalDimitri BultéAnnelies MondelaersHamide AslanLuis RivasLouis MaesGuy CaljonPublished in: Parasites & vectors (2020)
Recurrent in vitro and in vivo MIL exposure evokes a number of very subtle phenotypic and genotypic changes which could make promastigotes less susceptible to MIL without attaining full resistance. These changes did not significantly impact on infection in the sand fly vector.