Pterostilbene reduces oxidative stress, prevents hypertrophy and preserves systolic function of right ventricle in cor pulmonale model.
Denise Dos Santos LacerdaPatrick TürckBruna Gazzi de Lima-SeolinRafael ColomboVanessa Duarte OrtizJéssica Hellen Poletto BonettoCristina Campos-CarraroSara Elis BianchiAdriane Belló-KleinValquiria Linck BassaniAlex Sander da Rosa AraujoPublished in: British journal of pharmacology (2017)
The PTS : HPβCD complex prevented the maladaptative remodelling and protected systolic function in the RV of rats with pulmonary hypertension. These cardioprotective mechanisms may be related, in part, to the antioxidant potential of PTS, favoured by the increased p.o. bioavailability promoted by the presence of HPβCD in the complex.