Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours.
Devalingam MahalingamManish R PatelJasgit C SachdevLowell L HartNiels HalamaRamesh K RamanathanJohn SarantopoulosDirk VölkelAshraf YoussefFloris A de JongApostolia-Maria TsimberidouPublished in: British journal of clinical pharmacology (2020)
Imalumab had a maximum tolerated dose of 37.5 mg/kg every 2 weeks in patients with advanced solid tumours, with a biologically active dose of 10 mg/kg weekly. Further investigation will help define the role of oxMIF as a cancer treatment target.