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Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights.

Vanesa GottifrediLisa Wiesmuller
Published in: Cancers (2020)
In this Special Issue, we would like to focus on the various functions of the RAD52 helicase-like protein and the current implications of such findings for cancer treatment. Over the last few years, various laboratories have discovered particular activities of mammalian RAD52-both in S and M phase-that are distinct from the auxiliary role of yeast RAD52 in homologous recombination. At DNA double-strand breaks, RAD52 was demonstrated to spur alternative pathways to compensate for the loss of homologous recombination functions. At collapsed replication forks, RAD52 activates break-induced replication. In the M phase, RAD52 promotes the finalization of DNA replication. Its compensatory role in the resolution of DNA double-strand breaks has put RAD52 in the focus of synthetic lethal strategies, which is particularly relevant for cancer treatment.
Keyphrases
  • dna repair
  • dna damage
  • single molecule
  • circulating tumor
  • endothelial cells
  • diabetic rats