Changes in the proteome and secretome of rat liver sinusoidal endothelial cells during early primary culture and effects of dexamethasone.

Ruomei LiSabin BhandariInigo Martinez-ZubiaurreJack-Ansgar BruunIlona UrbarovaBård SmedsrødJaione Simón-Santamaria Karen Kristine Sørensen

Published in: PloS one (2022)

Rat LSECs become activated towards a pro-inflammatory phenotype during early culture. Dexamethasone represses LSEC activation, inhibits apoptosis, and improves cell viability.

Keyphrases

oxidative stress
endothelial cells
high dose
low dose
endoplasmic reticulum stress
cell death
cell cycle arrest
cell proliferation