Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients.

Junghee J ShinJason CatanzaroJennifer R YonkofOttavia DelmonteKeith SaccoMin Sun ShinSrikar ReddyPaula J WhittingtonGary SofferPeter J MustilloKathleen E SullivanLuigi D NotarangeloRoshini S AbrahamNeil RombergInsoo Kang

Published in: Journal of clinical immunology (2021)

Our findings support that recurrent infections and non-adherence to prophylaxis promote early CD8+ T-cell senescence in CD40L deficiency. Premature senescence may increase malignant susceptibilities and further exacerbate infectious risk in CD40L-deficient patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
type diabetes
patient reported outcomes
metabolic syndrome
risk factors
nk cells