Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel.

Tultul SahaJoydeep AounParamita SarkarAndrea J BourdelaisDaniel G BadenNormand LeblancJohn M HamlynOwen M Woodward Kazi Mirajul Hoque

Published in: Pharmaceutical biology (2021)

A cucurbitacin-like analog present in CCE activates TMEM16A channels, which may have therapeutic potential in cystic fibrosis and intestinal hypodynamic disorders.

Keyphrases

cystic fibrosis
pseudomonas aeruginosa
oxidative stress
lung function
anti inflammatory