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Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice.

Robert H OakleyMatthew J CampenMichael L PaffettXin ChenZhongjing WangTraci L ParryCarolyn HillhouseJohn A CidlowskiMonte S Willis
Published in: BMC medical genetics (2018)
The differentially expressed genes in MuRF1-/- and MuRF1 Tg + RV after CH have common functional annotations related to oxidoreductase (including antioxidant) and transmembrane component functions. Moreover, the functionally-enhanced MuRF1-/- hearts regulate genes related to transcription, homeobox proteins, and kinases/phosphorylation. These studies also reveal potential indirect effects of MuRF1 through regulating Rreb-1, and they reveal mechanisms by which MuRF1 may transcriptionally regulate anti-oxidant systems in the face of right heart failure.
Keyphrases
  • genome wide
  • heart failure
  • skeletal muscle
  • mycobacterium tuberculosis
  • gene expression
  • oxidative stress
  • single cell
  • dna methylation
  • left ventricular
  • risk assessment
  • genome wide identification
  • heat shock