Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2.
Atsushi ShiozakiHiroyuki InoueHiroki ShimizuToshiyuki KosugaKenichi TakemotoMichihiro KudouTakuma OhashiTomohiro AritaHirotaka KonishiShuhei KomatsuTakeshi KubotaHitoshi FujiwaraEigo OtsujiPublished in: Annals of surgical oncology (2023)
Based on the present results, TRPV2 and SLC12A2 are involved in the maintenance of CSCs, and their specific inhibitors, tranilast and furosemide, respectively, have potential as targeted therapeutic agents for EAC.