Silica-coated gold nanorods with hydrophobic modification show both enhanced two-photon fluorescence and ultrasound drug release.
Evan N MuellerTalaial B AlinaShane D CurrySaheli GangulyJennifer N ChaAndrew P GoodwinPublished in: Journal of materials chemistry. B (2022)
Hydrophobically-modified silica-coated gold nanorods are presented here as multifunctional theranostic agents. A single modification both increases two-photon fluorescence and promotes cavitation-based acoustic signal for imaging. A two-fold greater release of small molecule drugs was observed under ultrasound-mediated conditions as compared to passive release without ultrasound.
Keyphrases
- drug release
- small molecule
- magnetic resonance imaging
- drug delivery
- single molecule
- ultrasound guided
- high resolution
- contrast enhanced ultrasound
- living cells
- reduced graphene oxide
- photodynamic therapy
- energy transfer
- cancer therapy
- computed tomography
- gold nanoparticles
- mass spectrometry
- ionic liquid
- metal organic framework