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A gain-of-function filamin A mutation in mouse platelets induces thrombus instability.

Frédéric AdamAlexandre KauskotLamia LamraniJean SolarzChristelle SoukaseumChristelle RepérantCecile V DenisHana RaslovaJean-Philippe RosaMarijke Bryckaert
Published in: Journal of thrombosis and haemostasis : JTH (2022)
This study shows that the FlnA mutation found in the male patient induced gain of platelet functions in vitro, but thrombus instability in vivo. Implications for the role of FLNa in physiology of thrombus formation are discussed.
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