Chronic Voluntary Binge Ethanol Consumption Causes Sex-Specific Differences in Microglial Signaling Pathways and Withdrawal-associated Behaviors in Mice.

Meera RathJennifer GuerguesJoao P C PinhoPing ZhangTruc G NguyenKaley A MacFadyenJoanna PerisJay P McLaughlinStanley M Stevens Bin Liu

Published in: Alcoholism, clinical and experimental research (2020)

Taken together, our findings revealed sex-specific changes in EtOH withdrawal-associated behaviors and signaling pathways in the mouse brain microglia and may help advance our understanding of the molecular, cellular, and behavioral changes related to human binge EtOH consumption.

Keyphrases

signaling pathway
inflammatory response
endothelial cells
neuropathic pain
pi k akt
induced pluripotent stem cells
induced apoptosis
lipopolysaccharide induced
lps induced
high fat diet induced
single cell
spinal cord
metabolic syndrome
spinal cord injury
wild type