Combined Impact of Smoking and Early-Life Exposures on Adult Lung Function Trajectories.
James P AllinsonRebecca J HardyGavin C DonaldsonSeif O ShaheenDiana KuhJadwiga A WedzichaPublished in: American journal of respiratory and critical care medicine (2017)
Besides accelerating adult FEV1 decline, cigarette smoking also modifies how early-life exposures impact on both midlife FEV1 and FVC. These findings are consistent with smoking impairing pulmonary development during adolescence or early adulthood, thereby preventing catch-up from earlier acquired deficits.