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Parabiosis Discriminates the Circulating, Endothelial, and Parenchymal Contributions of Endogenous Tissue-Type Plasminogen Activator to Stroke.

Jonathane FuronFlorent LebrunMervé YetimDamien LevardPauline MarieCyrille OrsetSara Martinez de LizarrondoDenis VivienCarine Ali
Published in: Stroke (2024)
Together, our data reveal that during thromboembolic stroke, endogenous circulating tPA from endothelial cells sustains a spontaneous recanalization and reperfusion of the tissue, thus, limiting the extension of ischemic lesions. In this context, the impact of endogenous parenchymal tPA is limited.
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