Chloride Conductance, Nasal Potential Difference and Cystic Fibrosis Pathophysiology.
Elenara da Fonseca Andrade ProcianoyFernando Antônio de Abreu E SilvaPaulo José Cauduro MarósticaPaul M QuintonPublished in: Lung (2019)
The anion permeability through CFTR, mainly chloride, but bicarbonate as well, is the most critical factor in CF airway pathophysiology. Treatments primarily directed to correct CFTR function and/or airway acidity are clearly a priority.