Genotypic and phenotypic characteristics of Korean children with childhood-onset Leber's hereditary optic neuropathy.
Ye Jin AhnYooyeon ParkSun Young ShinHyojin ChaeMyungshin KimShin Hae ParkPublished in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)
Involvement of secondary mitochondrial mutations was confirmed in patients with childhood-onset LHON. Characteristic clinical features of childhood-onset LHON included a higher proportion of subacute or insidious onset of symptoms, better VA, higher spontaneous recovery, and asymmetrical ocular involvement.