Sinomenine Alleviates Rheumatoid Arthritis by Suppressing the PI3K-Akt Signaling Pathway, as Demonstrated Through Network Pharmacology, Molecular Docking, and Experimental Validation.
Qingyang LiuJian WangChunhui DingYing ChuFengying JiangYunxia HuHaifeng LiQiubo WangPublished in: Drug design, development and therapy (2024)
By utilizing network pharmacology, molecular modeling, and in vitro/in vivo validation, this study demonstrates that SIN can alleviate RA by inhibiting the PI3K-Akt signaling pathway. These findings enhance the understanding of the therapeutic mechanisms of SIN in RA, offering a stronger theoretical foundation for its future clinical application.
Keyphrases
- signaling pathway
- rheumatoid arthritis
- molecular docking
- disease activity
- pi k akt
- epithelial mesenchymal transition
- ankylosing spondylitis
- molecular dynamics simulations
- induced apoptosis
- interstitial lung disease
- systemic lupus erythematosus
- current status
- mouse model
- systemic sclerosis
- oxidative stress
- endoplasmic reticulum stress