An Integrated Approach Based on Network Pharmacology Combined with Experimental Verification Reveals AMPK/PI3K/Akt Signaling is an Important Way for the Anti-Type 2 Diabetic Activity of Silkworm Excrement.

Huxinyue DuanQing ZhangJia LiuRuolan LiWei PengChun-Jie Wu

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2021)

Our results suggested AMPK/PI3K/Akt signaling is an important way for the anti-type 2 diabetic activity of silkworm excrement by using an integrated approach based on network pharmacology combined with experimental verification.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
cell proliferation
type diabetes
skeletal muscle
wound healing
protein kinase
cell death