A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue.

Vinayak JuvekarMyoung Ki ChoHyo Won LeeDong Joon LeeHyuk KangJu Man SongJong Tae JeHwan Myung Kim

Published in: Chemical communications (Cambridge, England) (2021)

A cyclocyanine (CC)-based organic small molecule two-photon (TP) fluorescent probe (CCNa1) was developed for mitochondrial sodium ion sensing. CCNa1 exhibits a low solvatochromic shift and strong TP fluorescence enhancement at 575 nm upon binding to Na+ and is insensitive to other metal ions and to pH. CCNa1 demonstrated fast cell loading ability, biocompatibility, and sensitive response to mitochondrial Na+ influx in live cells and mouse brain tissue.

Keyphrases

fluorescent probe
living cells
small molecule
oxidative stress
single molecule
induced apoptosis
quantum dots
single cell
cell therapy
cell cycle arrest
photodynamic therapy
aqueous solution
cell death
mesenchymal stem cells
energy transfer