Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells.
Sarah TrouvilliezJulien CiceroRomain LévêqueLéo AubertCyril CorbetAlexandre Van OutryveKarolin StreulePierre-Olivier AngrandPamela VölkelRomain MagnezGuillaume BrysbaertCaroline MysiorekFabien GosseletRoland BouretteEric AdriaenssensXavier ThuruChann LagadecJérôme de RuyckVéronique Orian-RousseauXuefen Le BourhisRobert-Alain ToillonPublished in: Journal of experimental & clinical cancer research : CR (2022)
Collectively, our results suggest that blocking the CD44v3/TrkA interaction can be a new therapeutic option for triple-negative breast cancers.
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