Acute Hemodynamic Effects and Tolerability of Phosphodiesterase-1 Inhibition With ITI-214 in Human Systolic Heart Failure.
Nisha A GilotraAdam D DeVoreThomas J PovsicAllison G HaysVirginia S HahnTolu A AgunbiadeAllison DeLongAndrew SatlinRichard ChenRobert E DavisDavid A KassPublished in: Circulation. Heart failure (2021)
Single-dose ITI-214 is well-tolerated and confers inodilator effects in humans with heart failure with reduced ejection fraction. Further investigations of its therapeutic utility are warranted. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03387215.