Assessment of Aging-Related Function Variations of P-gp Transporter in Old-Elderly Chinese CHF Patients Based on Modeling and Simulation.

Cheng CuiYuchen QuJie En Valerie SiaZhu ZhuYang WangJing LingHaiyan LiYan JiangJie PanDongyang Liu

Published in: Clinical pharmacokinetics (2022)

Aging might be a significant risk factor for elevated systemic exposure to DAB and digoxin by reducing P-gp-mediated efflux in the Chinese old elderly population.

Keyphrases

end stage renal disease
ejection fraction
middle aged
chronic kidney disease
newly diagnosed
peritoneal dialysis
patient reported outcomes