The Logic of Carotid Body Connectivity to the Brain.
Tymoteusz ZeraDavi José A MoraesMelina P da SilvaJames P FisherJulian F R PatonPublished in: Physiology (Bethesda, Md.) (2020)
The carotid body has emerged as a therapeutic target for cardio-respiratory-metabolic diseases. With the expansive functions of the chemoreflex, we sought mechanisms to explain differential control of individual responses. We purport a remarkable correlation between phenotype of a chemosensory unit (glomus cell-sensory afferent) with a distinct component of the reflex response. This logic could permit differential modulation of distinct chemoreflex responses, a strategy ideal for therapeutic exploitation.