Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain.
P H C KremerB P C KoelemanL PawlikowskaS WeinsheimerN BendjilaliS SidneyJ G ZaroffGabriël J E RinkelL H van den BergY M RuigrokG A P de KortJ H VeldinkH KimC J M KlijnPublished in: Journal of neurology, neurosurgery, and psychiatry (2014)
Our meta-analysis of two Caucasian cohorts did not show an association between five aneurysm-associated loci and sporadic brain AVM. Possible involvement of SOX-17 and RBBP8, genes involved in cell cycle progression, deserves further investigation.
Keyphrases
- cell cycle
- genome wide
- systematic review
- resting state
- white matter
- cell proliferation
- late onset
- genome wide association study
- amyotrophic lateral sclerosis
- functional connectivity
- coronary artery
- stem cells
- genome wide association
- transcription factor
- dna methylation
- cerebral ischemia
- meta analyses
- multiple sclerosis
- copy number
- gene expression
- brain injury
- abdominal aortic aneurysm