Molecular signatures and clinical outcomes of transplant glomerulopathy stratified by microvascular inflammation and donor-specific antibody.

Michelle LubetzkyNicole HaydePilib Ó BroinMaria AjaimyYi BaoOmar MohammedDaniel SchwartzJames PullmanEnver Akalin

Published in: Clinical transplantation (2019)

Graft survival in TG is significantly worse in the presence of MVI. Gene expression profiles of MVI+ TG resemble antibody-mediated rejection while gene expression profiles of MVI- TG resemble cell-mediated rejection regardless of DSA status.

Keyphrases

genome wide
copy number
oxidative stress
single cell
cell therapy
stem cells
bone marrow
free survival
single molecule