Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation.

Deidiane Elisa RibeiroHeidi K MüllerBetina ElfvingAmanda EskelundSamia Rl JocaGregers Wegener

Published in: Journal of psychopharmacology (Oxford, England) (2019)

P2X7R blockade induces an antidepressant-like effect associated with increased levels of BDNF-AKT-p70 S6 kinase in the ventral hippocampus, which may be mediated by tropomyosin-related kinase B (TRKB) receptor activation supporting the notion of P2X7R antagonism as a potential new antidepressant strategy.

Keyphrases

major depressive disorder
spinal cord
stress induced
tyrosine kinase
binding protein
deep brain stimulation
climate change