Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect.

Wenkai ChenWenping LinNaichun YuLinlin ZhangZuoxing WuYongjie ChenZongguang LiFengqing GongNa LiXiaohui ChenXu HeYue WuXiangchen ZengYuting YuehRen Xu Guangrong Ji

Published in: International journal of nanomedicine (2022)

The potent Drp1 agonist, rifampicin, induced OS apoptosis and exosome loading, improving OS targeting and mouse survival rates. EXO-RIF is a promising strategy for the treatment of diverse malignancies.

Keyphrases

oxidative stress
pulmonary tuberculosis
diabetic rats
cell cycle arrest
endoplasmic reticulum stress
mycobacterium tuberculosis
cell death
high glucose
drug induced
anti inflammatory
combination therapy
signaling pathway
drug delivery
free survival
replacement therapy