Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.

Colleen Lacey Theone S E PatersonJodie R Gawryluknull null

Published in: PloS one (2024)

The current study partially replicated and extended previous findings from an earlier multimodal study (Honea 2009). Future studies should clarify APOE mechanisms in healthy ageing by adding other imaging, cognitive, and lifestyle metrics and longitudinal design in larger sample sizes.

Keyphrases

physical activity
cardiovascular disease
metabolic syndrome
cognitive decline
multiple sclerosis
adipose tissue
weight loss
pain management
insulin resistance
mild cognitive impairment
current status
subarachnoid hemorrhage