Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.

Rosa VentrellaSun K KimJennifer SheridanAline GrataEnzo BresteauOsama HassanEve E SuvaPeter WalentekBrian J Mitchell

Published in: bioRxiv : the preprint server for biology (2023)

Cell extrusion typically occurs unidirectionally. We have identified a single population of multiciliated cells that extrudes bidirectionally: Notch-driven basal extrusion and Piezo 1-mediated apical extrusion.

Keyphrases

single cell
cell therapy
cell proliferation
stem cells
cell cycle arrest
cell death
endoplasmic reticulum stress