In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma.
Sophie OrtonRebecca KarkiaDenis MustafovSeley GharaneiMaria BraoudakiAlice FilipeSuzana PanfilovSayeh SaraviNabeel KhanIoannis KyrouEmmanouil KarterisJayanta ChatterjeeHarpal S RandevaPublished in: Cancers (2024)
Our data indicate that PTPRD may have potential as a biomarker for malignancies such as EC and GBM, further implicating asprosin as a potential metabolic regulator in these cancers. Future studies are needed to explore the potential molecular mechanisms/signalling pathways that link PTPRD and asprosin in cancer.