Park7 protects retinal ganglion cells and promotes functional preservation after optic nerve crush via regulation of the Nrf2 signaling pathway.

Lingyi OuyangTao HeYiqiao Xing

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2023)

Park7 downregulation enhanced RGC injury and decreased retinal electrophysiological response and OMR after ONC in mice via the Keap1-Nrf2-HO-1 signaling pathway. Park7 may have neuroprotective effects and could represent a novel way to treat optic neuropathy.

Keyphrases

optic nerve
signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
oxidative stress
optical coherence tomography
epithelial mesenchymal transition
cell proliferation
endoplasmic reticulum stress
high fat diet induced
diabetic retinopathy
cell death
adipose tissue