Sarcoehrenbergilides D-F: cytotoxic cembrene diterpenoids from the soft coral Sarcophyton ehrenbergi .

Mohamed-Elamir F HegazyTarik A MohamedAbdelsamed I ElshamyAhmed R HamedMahmoud A A IbrahimShinji OhtaAkemi UmeyamaPaul W ParéThomas Efferth

Published in: RSC advances (2019)

A solvent extract of the soft coral Sarcophyton ehrenbergi afforded cembrene diterpenoids, sarcoehrenbergilid D-F (1-3). Chemical structures were established by modern spectroscopic techniques with absolute stereochemistries determined by circular dichroism (CD) and time-dependent density functional theory electronic CD calculations (TDDFT-ECD). Cytotoxicity activities for 1-3 were evaluated against three human cancer cell lines: lung (A549), colon (Caco-2) and liver (HepG2).

Keyphrases

density functional theory
molecular dynamics
endothelial cells
papillary thyroid
molecular docking
nk cells
oxidative stress
squamous cell
high resolution
induced pluripotent stem cells
molecular dynamics simulations
squamous cell carcinoma
lymph node metastasis