Cytotoxicity of fac -Mn(CO) 3 complexes with a bidentate quinoline ligand towards triple negative breast cancer.

Danira Ashraf Habashy Rabaa M Khaled Amr Y Ahmed Krzysztof Radacki Salma K Ahmed Engy K Tharwat Hana Magdy Alaa Zeinhom Ahmed M Mansour

Published in: Dalton transactions (Cambridge, England : 2003) (2022)

The cytotoxicity of two tricarbonyl Mn(I) complexes of the general formula fac -[MnBr(CO) 3 L] (L = quinoline-2-carboxaldehyde (A) and 8-amino quinoline (B)) towards triple negative breast cancer (MDA-MB-231) was reported. Complexes A and B released CO when exposed to 468 nm light. Compound B has a dose-dependent cytotoxicity, with half maximal inhibitory concentration values of 19.62 μM and 11.43 μM before and after illumination, respectively. Co-treatment of MDA-MB-231 with paclitaxel (30 nM) and complex B (10 μM) resulted in a 50% reduction in cell viability.

Keyphrases

molecular docking
breast cancer cells
photodynamic therapy
room temperature
resistance training
human milk
blood pressure
cell proliferation
molecular dynamics simulations
high intensity
smoking cessation
chemotherapy induced