AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1.

Israr AhmadAdam MolyvdasMing-Yuan JianTing ZhouAmie M TraylorHuachun CuiGang LiuWeifeng SongAnupam AgarwalTamas JillingSaurabh AggarwalSadis Matalon

Published in: The European respiratory journal (2021)

Our data indicate that the primary mechanism for the protective action of AICAR in toxic gas injury is by upregulating lung HO-1 levels.

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